飞行员血液同型半胱氨酸与心血管疾病的相关性研究

摘要：目的 研究飞行员血液同型半胱氨酸(homocysteine,Hcy)水平变化,预测飞行员心血管事件的发生. 方法 将163例飞行员和60例男性健康地面工作人员(对照组)按年龄分别设21～30岁、31～40岁和41～50岁组;同时按飞行时间将飞行员分别设≤1000 h、1001～2000 h、2001～3000 h和3001～4000 h组;采用全自动生化分析仪测定Hcy浓度. 结果 飞行员组血液Hcy浓度为(9.86±4.45)μmol/L,对照组为(7.10±1.77)μmol/L.两组比较显示飞行员组血液Hcy明显高于对照组(t=4.67,P＜0.01);在不同年龄组血液Hcy测定中,对照组21～30岁组与41～50岁组差异显著(P＜0.05),飞行员不同年龄组之间差异均显著(P＜0.05或P＜0.01);在不同飞行时间血液Hcy测定中,1001～2000 h组、2001～3000 h组均与≤1000 h组差异显著(P＜0.01).同一年龄组中,飞行员血液Hcy浓度均高于对照组(t=3.893、6.221、3.193,P＜0.01). 结论 测定血液Hcy可预测飞行员心血管事件发生的危险性,应针对飞行员血液Hcy升高采取强有力的干预措施,从而有效预防飞行员冠心病的发生. Abstract： Objective To study the change of homocysteine (Hcy) concerntration in pilot's blood and to predict the occurrence of cardiovascular events of pilots. Methods One hundred and sixty-three pilots and 60 male health ground service personnel were selected as pilot and control groups and respectively divided by age as 21-30, 31-40 and 41-50 yrs sub-groups. Pilots were also grouped into ≤ 1000 h, 1001-2000 h, 2001-3000 h and 3001-4000 h sub-groups by flying hours. The concentration of Hcy were detected by using automatic biochemical analyzer. Results The Hcy concentration in pilot group was (9.86±4.45) μmol/L comparing to (7.10±1.77) μmol/L in control group and the difference between groups was significant (t=4.67, P＜0.01). For the Hcy change by age, significant differences were between sub-group 21-30 yrs and 41-50 yrs in control group (P＜0.05), and between each two sub-groups in pilot g